关于“不要留下遗憾”的英语表达，综合权威资料整理如下：

一、核心表达

核心短语

- Don't leave any regrets.

- Don't have any regrets.

- Live without regrets.

- Make the most of every opportunity without any regrets.

扩展表达

- Spare no effort, leave no regret.

- Whatever you do, try to do it so that you won't have any regrets afterwards.

二、使用建议

语境选择：

该表达适用于鼓励人们勇敢追梦、珍惜当下的场景，如职业选择、人际关系或人生规划。

情感共鸣：通过"Laugh or cry as you like"等呼应性表达，可增强情感共鸣。

三、类似表达参考

人生短暂，及时行乐：

"Life is short, enjoy it while you can."

勇敢追梦：

"Chase your dreams without fear of failure."

机会难得：

"Seize the day, for opportunities don't come twice."

建议优先采用"Live without regrets."作为经典表达，其简洁性与感染力更符合英语表达习惯。