英语手抄报内容伤感的话，可以从以下几个方面来构思：

失去与怀念

"你离开以后，我很自由，也很落寞。"

"你是我最不想见到的人，却是我天天想念的人。"

"我一生健忘，唯有你，难忘。"

成长的痛苦

"最大的悲哀莫过于长大，从此，笑不再纯碎，哭不再彻底。"

生命的无常

"从中传来死亡的伤感乐曲。"

感恩与珍惜

"We are supposed to express our gratitude to others on Thanksgiving Day. However, we should feel gratitude every day. God has two dwellings, one in heaven, and the other in a meek and thankful heart. Be grateful to others is a way to show your love."

友谊与互助

"The timid hand stretched forth to aid A brother in his need, A kindly word in grief's dark hour That proves a friend indeed ；"

时间的流逝

"One cannot put back the clock.时钟不能倒转。"

真实的感受

"It is no use" （这句话虽然简短，但可以引发读者对真实感受的思考）

这些内容可以根据手抄报的整体设计和风格进行选择和调整，以达到伤感的氛围。希望这些建议对你有所帮助!